I have had customers reserve the frontage portion of their property for retail and build typical storage buildings behind it on long, narrow plots. There is also an interesting topic here about building Mini-Office-Warehouses:
Mini-office-warehouse
Retail combined with climate control is an interesting idea but would probably face a huge zoning battle. You'd probably want the loading/unloading to be in the back - out of sight of the retail customers.

Steve Smith
Custom Site Plans
SteveSmith@ByteOne.com